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Core Content

Rationale, Design, and Analysis of SMARTs.

M1
Adaptive Interventions: Introductory Review
M4
Primary Aim Data Analyses in a SMART, Part I
M5
Primary Aim Data Analyses in a SMART, Part II
M6
Pilot Studies in Adaptive Intervention Research
M7
Secondary Aims Using Data from a SMART
Refer back to modules at any time.
Virtual Content

Hands-on Analytics

Software Bundle [Lightweight Version]

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Installation Instructions

This lightweight version of the software bundle is like a "Quick Start" allowing one to quickly jump into the R code implementing workflows covered in Module V2 and Module V3. Installing the full version of the software bundle is optional.

Software Bundle [Full Version]

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This software bundles the simulated data set and R code used in the Code Along Portion of Module V2 and Module V3 as well as Quarto files used to generate the html files in the Follow-Along portion of Module V2 and Module V3 into an R project.

V1
Tips for Writing a SMART Grant
V3
Secondary Aims Analyses in a SMART
V4
Tips for Writing a Primary Aim Manuscript for a SMART Study
NIH R01 Grant Template

For constructing an optimized adaptive intervention using a SMART.

Scroll to begin.

R01 Smart Grant Template: Specific Aims

Introduction to Specific Aims

Describe the general education, special education or public health problem that requires intervention or that needs to be addressed.

One paragraph

Here you may also provide any other background that the reader may need to have in order to understand the rest of the specific aims page.

Primary Aim

To test [insert the primary aim comparison; see example aims] on [insert primary outcome] (primary outcome), [insert list of secondary outcomes] (secondary).

Hypothesis: [insert the study’s primary hypothesis]

The Primary Aim is (i) the most important causal question you seek to answer and (ii) seek to provide assurances about. - These two ideas often work against each other, so find the sweet spot. This takes months.- Describe the primary vs secondary outcome(s).

Secondary Aim 1

To estimate/examine [insert a secondary aim comparison; see example aims] on the primary and secondary outcomes.

Hypothesis: [insert secondary hypothesis 1]

- As you move down the aims, you move from (i) “testing” to “exploring” (i.e, you provide fewer assurances about statistical uncertainty), (ii) easier to understand aims to more complex ones, (iii) less to more exciting scientific questions- Effect moderation always comes before mediation- Avoid observational study aims (only use causal). These can be added to an “Additional Analyses” section of the grant.

Secondary Aim 2

To estimate/examine/explore [insert a secondary aim comparison; see example aims] on the primary and secondary outcomes.

Hypothesis: [insert secondary hypothesis 2]

- As you move down the aims, you move from (i) “testing” to “exploring” (i.e, you provide fewer assurances about statistical uncertainty), (ii) easier to understand aims to more complex ones, (iii) less to more exciting scientific questions- Effect moderation always comes before mediation- Avoid observational study aims (only use causal). These can be added to an “Additional Analyses” section of the grant.

Impact

[In one sentence, summarize how the answers to these questions/aims will lead to an adaptive intervention that will improve outcomes and solve the general problem you started with. In a second sentence, explain how this study is aligned with strategic aims set out by the funding agency.]

Two lines max.

Specific Aims

Introduction
Primary Aim
Secondary Aim 1
Secondary Aim 2
Impact

Innovation

Specific Aims

Introduction
Primary Aim
Secondary Aim 1
Secondary Aim 2
Impact

Approach

Overview of Study Design
Randomization
Participants
Intervention Components
Implementation Strategies
Measures
Statistical Analysis Plan
Sample Size & Power
Alternate Study Designs Considered

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Comprehensive Program for Adaptive Interventions Training in Education