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Core Content
Rationale, Design, and Analysis of SMARTs.
Adaptive Interventions: Introductory Review
SMART Trials: Introductory Review
SMART Case Studies
Primary Aim Data Analyses in a SMART, Part I
Primary Aim Data Analyses in a SMART, Part II
Pilot Studies in Adaptive Intervention Research
Secondary Aims Using Data from a SMART
Clustered SMARTs
Virtual Content
Hands-on Analytics
Software Bundle [Lightweight Version]
This lightweight version of the software bundle is like a "Quick Start" allowing one to quickly jump into the R code implementing workflows covered in Module V2 and Module V3. Installing the full version of the software bundle is optional.
Software Bundle [Full Version]
This software bundles the simulated data set and R code used in the Code Along Portion of Module V2 and Module V3 as well as Quarto files used to generate the html files in the Follow-Along portion of Module V2 and Module V3 into an R project.
Tips for Writing a SMART Grant
Primary Aims Analyses in a SMART
Secondary Aims Analyses in a SMART
Tips for Writing a Primary Aim Manuscript for a SMART Study
R01 Smart Grant Template: Specific Aims
Introduction to Specific Aims
Describe the general education, special education or public health problem that requires intervention or that needs to be addressed.
One paragraph
Here you may also provide any other background that the reader may need to have in order to understand the rest of the specific aims page.
Primary Aim
To test [insert the primary aim comparison; see example aims] on [insert primary outcome] (primary outcome), [insert list of secondary outcomes] (secondary).
Hypothesis: [insert the study’s primary hypothesis]
The Primary Aim is (i) the most important causal question you seek to answer and (ii) seek to provide assurances about. - These two ideas often work against each other, so find the sweet spot. This takes months.- Describe the primary vs secondary outcome(s).
Secondary Aim 1
To estimate/examine [insert a secondary aim comparison; see example aims] on the primary and secondary outcomes.
Hypothesis: [insert secondary hypothesis 1]
- As you move down the aims, you move from (i) “testing” to “exploring” (i.e, you provide fewer assurances about statistical uncertainty), (ii) easier to understand aims to more complex ones, (iii) less to more exciting scientific questions- Effect moderation always comes before mediation- Avoid observational study aims (only use causal). These can be added to an “Additional Analyses” section of the grant.
Secondary Aim 2
To estimate/examine/explore [insert a secondary aim comparison; see example aims] on the primary and secondary outcomes.
Hypothesis: [insert secondary hypothesis 2]
- As you move down the aims, you move from (i) “testing” to “exploring” (i.e, you provide fewer assurances about statistical uncertainty), (ii) easier to understand aims to more complex ones, (iii) less to more exciting scientific questions- Effect moderation always comes before mediation- Avoid observational study aims (only use causal). These can be added to an “Additional Analyses” section of the grant.
Impact
[In one sentence, summarize how the answers to these questions/aims will lead to an adaptive intervention that will improve outcomes and solve the general problem you started with. In a second sentence, explain how this study is aligned with strategic aims set out by the funding agency.]
Two lines max.
Innovation
